Apium graveolens (celery) is an edible and traditionally medicinal plant that is used\nworldwide, among others for the treatment of hypertension. Combining celery with antihypertensive\ndrugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the\nstudy is to assess the effects of administrating the celery extract on captopril pharmacokinetics.\nSprague-Dawley strain rats were divided into two groups (n = 6). Group I was given captopril\n(10 mg/kg Body Weight (BW)) orally, while Group II was pretreated with celery extract orally\n(40 mg/kg BW) an hour before administration of captopril. The blood samples were withdrawn\nat various intervals after drug administration. The captopril concentration was determined using\nliquid chromatographyââ?¬â??mass spectrometry (LC-MS/MS) and from the blood data, the values of Ke,\nCmax, Tmax, T1/2, and area under the curve (AUC) were calculated. The results showed that oral\nadministration of the celery extract increased Cmax (38.67%), T1/2 (37.84%), and AUC (58.10%) and\ndecreased Ke (27.45%) of captopril in Group II (celery + captopril) compared with Group I (captopril).\nIn conclusion, celery extract can alter the pharmacokinetic of captopril when given in combination.\nThe combination might be beneficial for the treatment of hypertension, as celery causes an increase in\nthe plasma level of captopril, which can enhance its efficacy
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